Scientific Publications & Abstracts
Scientific Publications
Clinical studies (sponsored)
RefluxStop™ 4-year Results:
Harsányi L, Kincses Z, Zehetner J, Altorjay Á. Treating acid reflux without compressing the food passageway: 4-year safety and clinical outcomes with the RefluxStop device in a prospective multicenter study. Surg Endosc. 2024;38(10):6060-9 https://doi.org/10.1007/s00464-024-11114-0.
Harsányi L, Kincses Z, Altorjay Á. Acid Reflux Management with the RefluxStop Implant: A Prospective Multicenter Trial with 3-Year Outcomes. Digestive Diseases and Sciences. 2025;70(2):665-74 https://doi.org/10.1007/s10620-024-08788-w.
1-year Landmark Study Results:
Bjelović M, Harsányi L, Altorjay Á, Kincses Z, Forsell P. Non-active implantable device treating acid reflux with a new dynamic treatment approach: 1-year results. BMC Surg. 2020;20(1):159 https://doi.org/10.1186/s12893-020-00794-9.
Clinical studies (real-world)
Lehmann T, Šimkus M, Oehler C. A retrospective study assessing RefluxStop surgery for gastroesophageal reflux disease: Clinical outcomes in 79 patients from Germany. Surgery Open Science. 2025;23:9-15 https://doi.org/10.1016/j.sopen.2024.12.003
Feka J, Saad M, Boyle N, Paireder M, Kristo I, Rieder E, et al. Multicentric short term and safety study of ineffective esophageal motility patients treated with RefluxStop device. Scientific Reports. 2024;14(1):15425 https://doi.org/10.1038/s41598-024-65751-5.
Fringeli Y, Linas I, Kessler U, Zehetner J. Exploring the feasibility and safety of laparoscopic anti-reflux surgery with the new RefluxStop™ device: a retrospective cohort study of 40 patients. Swiss Med Wkly. 2024;154:3365 https://doi.org/10.57187/s.3365.
Fringeli Y, Linas I, Kessler U, Zehetner J. Laparoscopic Large Hiatal Hernia Repair With RefluxStop: Outcomes of Six Months Follow-up in Thirty Patients. Surg Laparosc Endosc Percutan Tech. 2024;34(2):143-9 https://doi.org/10.1097/sle.0000000000001256.
Fringeli Y, Linas I, Kessler U, Zehetner J. Short-term results of laparoscopic anti-reflux surgery with the RefluxStop device in patients with gastro-esophageal reflux disease and ineffective esophageal motility. Langenbecks Arch Surg. 2024;409(1):78 https://doi.org/10.1007/s00423-024-03264-5.
Description of the surgery
Stephan D, Borbely Y, Schoppmann SF. RefluxStop™ Therapy - a New Minimally Invasive Technology in Anti-reflux Surgery. Surg Technol Int. 2022 Nov 15;41:137-142. PMID: 36255718. Available at: https://pubmed.ncbi.nlm.nih.gov/36255718/
Health economics studies
Harper S, Grodzicki L, Mealing S, Gemmill L, Goldsmith PJ, Ahmed AR. Cost-effectiveness of a novel, non-active implantable device as a treatment for refractory gastro-esophageal reflux disease. J Med Econ. 2023;26(1):603-13 https://doi.org/10.1080/13696998.2023.2201063.
Harper S, Grodzicki L, Mealing S, Gemmill E, Goldsmith P, Ahmed A. Budget Impact of RefluxStop™ as a Treatment for Patients with Refractory Gastro-oesophageal Reflux Disease in the United Kingdom. J Health Econ Outcomes Res. 2024;11(1):1-7 https://doi.org/10.36469/001c.90924.
Harper S, Kartha M, Mealing S, Borbély YM, Zehetner J. Cost-effectiveness of the RefluxStop device for management of refractory gastroesophageal reflux disease in Switzerland. J Med Econ. 2024;27(1):805-15 https://doi.org/10.1080/13696998.2024.2362564.
Harper S, Kartha M, Mealing S, Pavanello M, Bonavina L. The Economic Impact of Introducing RefluxStop for Refractory Gastroesophageal Reflux Disease on the Italian Healthcare System. PharmacoEconomics - Open. 2024;8(6):935-43 https://doi.org/10.1007/s41669-024-00521-7.
Harper S, Kartha M, Mealing S, Lundell L. A cost-effectiveness analysis of RefluxStop against relevant therapeutic alternatives for chronic gastroesophageal reflux disease in Sweden. Expert Rev Pharmacoecon Outcomes Res. 2024:1-13 https://doi.org/10.1080/14737167.2024.2417774.
Abstracts, presentations & conference proceedings
Real-world clinical data
Borbély Y, Kroell D, Martinelli CDP, Haltmeier T, Prevost G. 442. RefluxStop Procedure as a Novel Technique for Management of Gastroesophageal Reflux Disease: Two-Year Follow-up Data at a Hospital in Switzerland. Diseases of the Esophagus. 2023;36(Supplement_2) https://doi.org/10.1093/dote/doad052.233.
Fringeli Y, Kessler U, Linas I, Zehetner J. Laparoscopic Hiatal Hernia Repair with RefluxStop: Outcomes in 30 Patients with a Minimal Follow-Up of 12 Months. British Journal of Surgery. 2023;110(Suppl5). Abstract ID: znad178.020. https://doi.org/10.1093/bjs/znad178.020.
Elshafei M. One-year Follow-up of 15 Patients With Gastroesophageal Reflux Disease Managed With the Novel Refluxstop Device. Presented at Høstmøtet 2023. Oslo, Norway. October 23-27, 2023 Available at https://issuu.com/brataas/docs/h_stm_tet2023-abstrakter page 8.
Zehetner J, Linas I, Kessler U, Fringeli Y. Reflux Patients with Ineffective Esophageal Motility: 12-Month Follow-up Results of Laparoscopic Hiatal Hernia Repair with RefluxStop. DDW ePoster Library. Zehetner J. 05/08/2023; 377862; Mo1339. Available at: https://eposters.ddw.org/ddw/2023/ddw-2023/377862/joerg.zehetner.gerd.patients.with.ineffective.esophageal.motility.3Cbr3E.html?f=menu%3D6%2Abrowseby%3D8%2Asortby%3D2%2Amedia%3D2%2Ace_id%3D2482%2Aot_id%3D27745%2Amarker%3D4154
Elshafei M, Lehmann T. RefluxStop implant for gastroesophageal reflux disease: clinical outcomes at almost 2 years in a pooled cohort of 158 patients from two German hospitals. Presented as poster at SAGES (Emerging Technology) 2024
Systematic reviews
Hoffsten J, Das S, Kartha M. EE479 The Cost of Treating Gastroesophageal Reflux Disease: A Systematic Review. Value in Health. 2023;26(12):S143 https://doi.org/10.1016/j.jval.2023.09.745.
Goldsmith P, Das S, Hoffsten J. OGBN O03 Quality of Life of Patients with Gastroesophageal Reflux Disease: Findings From a Systematic Literature Review. British Journal of Surgery. 2023;110(Supplement_8) https://doi.org/10.1093/bjs/znad348.025.
Health economics studies
Gaupset R, Eftang L. Cost-effectiveness assessment of RefluxStop for refractory gastroesophageal reflux disease in Norway. Presented at Høstmøtet 2023. Oslo, Norway. October 23-27, 2023. Available at: https://issuu.com/brataas/docs/h_stm_tet2023-abstrakter page 7.
Harper S, Kartha M, Mealing S, Bona D, Vincenti L, Renzi A, Bonavina L. EE296 A Nonactive Implant for the Treatment of Chronic Gastro-Oesophageal Reflux Disease: Cost-Effectiveness Analysis From an Italian Healthcare Payer Perspective. Value in Health. 2024;27(12):S112 https://doi.org/10.1016/j.jval.2024.10.578.
Harper S, Bui KH, Mealing S, Sánchez López D, Priego Jiménez P, Moreno Sanz C. EE437 Cost-Effectiveness Analysis of a Non-Active Implant for Chronic Gastro-Oesophageal Reflux Disease in Spain. Value in Health. 2024;27(12):S141-S2 https://doi.org/10.1016/j.jval.2024.10.718.
Harper S, Bui KH, Mealing S, Sánchez López D, Priego Jiménez P, Moreno Sanz C. EE607 Budget Impact Analysis of Refluxstop as a Treatment of Refractory Gastroesophageal Reflux Disease in Spain. Value in Health. 2024;27(12):S175 https://doi.org/10.1016/j.jval.2024.10.887.
RefluxStop™ is not available for sale in the US or Canada.
Please contact your Implantica representative for availability in your region.
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