Scientific Publications & Abstracts

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Clinical Studies

Prospective Clinical studies 

RefluxStop 5-year Results:
Harsányi L, Kincses Z, Veselinović M, Zehetner J, Altorjay Á. Five-year clinical outcomes of RefluxStop surgery in the treatment of acid reflux: a prospective multicenter trial of safety and effectiveness. Surg Endosc. 2025 Sep;39(9):6163-6179. doi: 10.1007/s00464-025-11979-9. Epub 2025 Jul 22. PMID: 40696212; PMCID: PMC12408713. https://pubmed.ncbi.nlm.nih.gov/40696212/

Harsányi L, Kincses Z, Veselinović M, Zehetner J, Altorjay Á. Food passageway-related sequelae in the RefluxStop prospective multicenter trial: patient-centric outcomes of dysphagia, odynophagia, gas-bloating, and inability to belch and/or vomit at 5 years. Surg Endosc. 2025 Jul;39(7):4615-4627. doi: 10.1007/s00464-025-11818-x. Epub 2025 Jun 20. PMID: 40542141; PMCID: PMC12222248. https://pubmed.ncbi.nlm.nih.gov/40542141/

RefluxStop 4-year Results:
Harsányi L, Kincses Z, Zehetner J, Altorjay Á. Treating acid reflux without compressing the food passageway: 4-year safety and clinical outcomes with the RefluxStop device in a prospective multicenter study. Surg Endosc. 2024;38(10):6060-6069. doi: 10.1007/s00464-024-11114-0. Epub 2024 Aug 13. PMID: 39138680; PMCID: PMC11458627. https://pubmed.ncbi.nlm.nih.gov/39138680/

RefluxStop 3-year Results:
Harsányi L, Kincses Z, Altorjay Á. Acid Reflux Management with the RefluxStop Implant: A Prospective Multicenter Trial with 3-Year Outcomes. Digestive Diseases and Sciences. 2025;70(2):665-674. doi: 10.1007/s10620-024-08788-w. Epub 2024 Dec 19. PMID: 39702779; PMCID: PMC11839859. https://pubmed.ncbi.nlm.nih.gov/39702779/

1-year Landmark Study Results:
Bjelović M, Harsányi L, Altorjay Á, Kincses Z, Forsell P. Non-active implantable device treating acid reflux with a new dynamic treatment approach: 1-year results. BMC Surg. 2020;20(1):159 https://doi.org/10.1186/s12893-020-00794-9.

Real-World and Observational Studies

Schoppmann SF, Zehetner J, Elshafei M, et al. Safety outcomes in 602 GERD patients treated by RefluxStop: a multi-center real-world study from 22 centers across six European countries. Sci Rep. 2026;16(1):18071. Published 2026 Apr 18. doi:10.1038/s41598-026-47034-3 https://pubmed.ncbi.nlm.nih.gov/42000769/

Additional Observational Cohort Studies

Fringeli Y, Linas I, Kessler U, Zehetner J. Exploring the feasibility and safety of laparoscopic anti-reflux surgery with the new RefluxStop device: a retrospective cohort study of 40 patients. Swiss Med Wkly. 2024;154:3365. doi: 10.57187/s.3365. PMID: 39137342. https://pubmed.ncbi.nlm.nih.gov/39137342/

Technical and Surgical Technique Studies

Elshafei M, Aiolfi A, Bonitta G, Bona D, Bonavina L. Learning Curve of the Laparoscopic RefluxStop Procedure for the Treatment of Gastroesophageal Reflux Disease. J Laparoendosc Adv Surg Tech A. 2025 Nov;35(11):849-855. doi: 10.1177/10926429251391166. Epub 2025 Oct 24. PMID: 41134373. https://pubmed.ncbi.nlm.nih.gov/41134373/ 

Stephan D, Borbely Y, Schoppmann SF. RefluxStop™ Therapy - a New Minimally Invasive Technology in Anti-reflux Surgery. Surg Technol Int. 2022 Nov 15;41:137-142. PMID: 36255718. https://pubmed.ncbi.nlm.nih.gov/36255718/ 

Reviews, Position Papers, and Expert Perspectives* 

Wang Q, Niu MM, Dang YC, Li RS, Liu XN, Bonavina L. [Strategies and innovative practices of European minimally invasive surgery for gastroesophageal reflux disease]. Zhonghua Wei Chang Wai Ke Za Zhi. 2026 Apr 25;29(4):468-477. Chinese. doi: 10.3760/cma.j.cn441530-20251208-00463. PMID: 42045711. https://pubmed.ncbi.nlm.nih.gov/42045711/

Mohamed MS, Assiri A, Abosheisha M, Omar I. Safety and clinical outcomes of RefluxStop procedure: systematic review and meta-analysis.
J Gastrointest Surg. 2026 Jun;30(6):102414. doi: 10.1016/j.gassur.2026.102414. Epub 2026 Apr 3. PMID: 41936998 https://pubmed.ncbi.nlm.nih.gov/41936998/

Cable J, Giuli R, Fox MR, Rosen RL, Valdovinos-García LR, Siboni S, Clarke JO, Johnston N, Samuels TL, Scarpignato C, Stein EM, Fass R, Remes-Troches JM, Khan A, Rahman AK, Lynch K, Jodorkovsky D, Vela MF, Vandenberg A, Kuo B, Ergun P, Jirapinyo SP, Asti E, Tolone S, Sheu EG, Salvador R, Sozzi M, Husain IA, Wu JC, Hobson A, Sharma NS, Lo WK, Duncan DR, Gyawali CP, Chan W, Sifrim D, Savarino E, de Bortoli N, Rogers BD. Gatherings in Esophagology: Innovations and Future Directions in the Diagnosis and Management of Reflux Disease. Ann N Y Acad Sci. 2026 Mar;1557(1):e70225. doi: 10.1111/nyas.70225. PMID: 41817458; PMCID: PMC12981296. https://pubmed.ncbi.nlm.nih.gov/41817458/

Aiolfi A, Bona D, Wang Q, Bonavina L. Reflections on surgery for hiatal hernia. Updates Surg. 2026 Feb;78(1):1-8. doi: 10.1007/s13304-025-02490-w. Epub 2025 Dec 22. PMID: 41430014. https://pubmed.ncbi.nlm.nih.gov/41430014/

Youssef MM, Watson AC, Profitt SA, Allaway M, Ongso Y, Sivakumar J, Kamal AN, Shimamura Y, Thompson SK, Watson DI, Duong CP, Liu DS. Current pharmacological and procedural treatments for gastro-oesophageal reflux disease: comprehensive review. BJS Open. 2025 Oct 30;9(6):zraf115. doi: 10.1093/bjsopen/zraf115. PMID: 41316734; PMCID: PMC12662798. https://pubmed.ncbi.nlm.nih.gov/41316734/

Hansson MR, Tsoposidis A, Analatos A, Lundell L, Kostic S, Thorell A, Håkanson B. Novel minimal invasive antireflux techniques: A systematic review. Scand J Surg. 2025 Oct 30:14574969251385759. doi: 10.1177/14574969251385759. Epub ahead of print. PMID: 41165082. https://pubmed.ncbi.nlm.nih.gov/41165082/

Rosen H, Sebesta C Jr, Sebesta MC, Sebesta C. Therapeutic Management of Gastroesophageal Reflux Disease (GERD)-Is There Something Between PPI and Fundoplication? An Overview. J Clin Med. 2025 Jan 9;14(2):362. doi: 10.3390/jcm14020362. PMID: 39860368; PMCID: PMC11766380. https://pubmed.ncbi.nlm.nih.gov/39860368/

Bonavina L. Individualizing the choice of surgical therapy for gastroesophageal reflux disease. Curr Opin Gastroenterol. 2025 Jul 1;41(4):245-250. doi: 10.1097/MOG.0000000000001082. Epub 2025 Feb 17. PMID: 39964431; PMCID: PMC12147730. https://pubmed.ncbi.nlm.nih.gov/39964431/

Zehetner, J., Hoffsten, J., Das, S. et al.Looking back on a gold standard: a systematic literature review of laparoscopic Nissen fundoplication as an anti-reflux treatment option. Eur Surg 56, 143–171 (2024). https://link.springer.com/article/10.1007/s10353-024-00836-z

Gensthaler L, Schoppmann SF. New Developments in Anti-Reflux Surgery: Where Are We Now? Visc Med. 2024 Oct;40(5):250-255. doi: 10.1159/000538117. Epub 2024 Apr 9. PMID: 39398392; PMCID: PMC11466450. https://pubmed.ncbi.nlm.nih.gov/39398392/

Labenz J, Schoppmann SF. Improving treatment of people with gastro-esophageal reflux disease refractory to proton pump inhibitors. Commun Med (Lond). 2024 Oct 14;4(1):200. doi: 10.1038/s43856-024-00632-6. PMID: 39397153; PMCID: PMC11471847. https://pubmed.ncbi.nlm.nih.gov/39397153/

D. Kollmann, C. Etyemez, R. Asari, et al. “Antireflux Surgery for Barrett's Esophagus: Where Do We Stand in Preventing Esophageal Adenocarcinoma?.” Annals of the New York Academy of Sciences1556, no. 1 (2026): e70196. https://pmc.ncbi.nlm.nih.gov/articles/PMC12880584/

Schoppmann SF. Alternative operative Verfahren zur Behandlung der gastroösophagealen Refluxerkrankung [Alternative Surgical Anti-Reflux Procedures]. Zentralbl Chir. 2021 Apr;146(2):210-214. German. doi: 10.1055/a-1369-9732. Epub 2021 Apr 13. PMID: 33851383. https://pubmed.ncbi.nlm.nih.gov/33851383/

Health Economics Studies

Cost-Effectiveness Studies

Harper S, Kartha M, Mealing S, Bona D, Vincenti L, Renzi A, Bonavina L. Cost-effectiveness of RefluxStop for gastroesophageal reflux disease: analysis from an Italian healthcare perspective. BMC Gastroenterol. 2026 Mar 24. doi: 10.1186/s12876-026-04747-z. Epub ahead of print. PMID: 41872758. https://pubmed.ncbi.nlm.nih.gov/41872758/

Harper S, Bui KH, Mealing S, Sanchez D, Jiménez PP, Sanz CM. Cost-Effectiveness of RefluxStop Versus Nissen Fundoplication and Proton Pump Inhibitors for Refractory Gastroesophageal Reflux Disease: A Spanish Healthcare Perspective. Pharmacoecon Open. 2026 Mar;10(2):249-263. doi: 10.1007/s41669-025-00636-5. Epub 2026 Jan 14. PMID: 41533326; PMCID: PMC13000083. https://pubmed.ncbi.nlm.nih.gov/41533326/

Harper S, Kartha M, Mealing S, Eftang L, Gaupset R. Cost-effectiveness of RefluxStop compared to proton pump inhibitors and Nissen fundoplication for management of persistent gastroesophageal reflux disease in Norway. Cost Eff Resour Alloc. 2025 Oct 29;23(1):63. doi: 10.1186/s12962-025-00665-1. PMID: 41163234; PMCID: PMC12573859. https://pubmed.ncbi.nlm.nih.gov/41163234/

Harper S, Kartha M, Mealing S, Lundell L. A cost-effectiveness analysis of RefluxStop against relevant therapeutic alternatives for chronic gastroesophageal reflux disease in Sweden. Expert Rev Pharmacoecon Outcomes Res. 2024 Oct 20:1-13. doi: 10.1080/14737167.2024.2417774. Epub ahead of print. PMID: 39428644. https://pubmed.ncbi.nlm.nih.gov/39428644/

Harper S, Kartha M, Mealing S, Borbély YM, Zehetner J. Cost-effectiveness of the RefluxStop device for management of refractory gastroesophageal reflux disease in Switzerland. J Med Econ. 2024 Jan-Dec;27(1):805-815. doi: 10.1080/13696998.2024.2362564. Epub 2024 Jun 18. PMID: 38820006. https://pubmed.ncbi.nlm.nih.gov/38820006/

Harper S, Grodzicki L, Mealing S, Gemmill L, Goldsmith PJ, Ahmed AR. Cost-effectiveness of a novel, non-active implantable device as a treatment for refractory gastro-esophageal reflux disease. J Med Econ. 2023 Jan-Dec;26(1):603-613. doi: 10.1080/13696998.2023.2201063. PMID: 37042668. https://pubmed.ncbi.nlm.nih.gov/37042668/

Budget-Impact Studies

Harper S, Grodzicki L, Mealing S, Gemmill E, Goldsmith P, Ahmed A. Budget Impact of RefluxStop™ as a Treatment for Patients with Refractory Gastro-oesophageal Reflux Disease in the United Kingdom. J Health Econ Outcomes Res. 2024 Jan 11;11(1):1-7. doi: 10.36469/001c.90924. PMID: 38222857; PMCID: PMC10787539. https://pubmed.ncbi.nlm.nih.gov/38222857/

Harper S, Kartha M, Mealing S, Pavanello M, Bonavina L. The Economic Impact of Introducing RefluxStop for Refractory Gastroesophageal Reflux Disease on the Italian Healthcare System. Pharmacoecon Open. 2024 Nov;8(6):935-943. doi: 10.1007/s41669-024-00521-7. Epub 2024 Aug 27. PMID: 39190268; PMCID: PMC11499547. https://pubmed.ncbi.nlm.nih.gov/39190268/

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Selected Published Abstracts

Borbély, Y., et al., RefluxStopTM: 3-Year Results of a Novel Procedure to Address Gastroesophageal Reflux Disease. Surgical Endoscopy, 2024. 38(1): p. S43.

Borbèly, Y., et al., RefluxStop - A NovelN Device to Address Gastroesophageal Reflux Disease in the Context of Esophageal Hypomotility. British Journal of Surgery, 2023. 110: p. v7. https://www.researchgate.net/publication/371468549_RefluxStop_-_A_Novel_Device_to_Address_Gastroesophageal_Reflux_Disease_in_the_Context_of_Esophageal_Hypomotility?__cf_chl_rt_tk=Sfts6I2pMTvhsYXtLfWLaefMmkIsQZ82L1zvdjwCaJ8-1787266441-1.0.1.1-uBCK8unlIIHWo4Mcz5NW2i6.WcN6XJdC9mIkCUF8AT4

Borbély, , et al., 442. REFLUXSTOP PROCEDURE AS A NOVEL TECHNIQUE FOR MANAGEMENT OF GASTROESOPHAGEAL REFLUX DISEASE: TWO-YEAR FOLLOW-UP DATA AT A HOSPITAL IN SWITZERLAND. Diseases of the Esophagus, 2023. 36(Supplement_2).
https://www.researchgate.net/publication/373575813_442_REFLUXSTOP_PROCEDURE_AS_A_NOVEL_TECHNIQUE_FOR_MANAGEMENT_OF_GASTROESOPHAGEAL_REFLUX_DISEASE_TWO-YEAR_FOLLOW-UP_DATA_AT_A_HOSPITAL_IN_SWITZERLAND

Lehmann, T., STRONG SYMPTOMATIC IMPROVEMENT AT 1 YEAR AND BEYOND FOLLOWING REFLUXSTOP SURGERY FOR GASTRO-ESOPHAGEAL REFLUX DISEASE: A 40-PATIENT COHORTT. Diseases of the Esophagus, 2024. 37: p. 79-80. https://www.researchgate.net/publication/383686661_481_STRONG_SYMPTOMATIC_IMPROVEMENT_AT_1_YEAR_AND_BEYOND_FOLLOWING_REFLUXSTOP_SURGERY_FOR_GASTRO-ESOPHAGEAL_REFLUX_DISEASE_A_40-PATIENT_COHORTT

Lehmann, T., M. Simkus, and C. Oehler, A RETROSPECTIVE CHART REVIEW OF 85 PATIENTS UNDERGOING THE REFLUXSTOP PROCEDURE TO MANAGE GASTROESOPHAGEAL REFLUX DISEASE: SAFETY AND EFFICACY. Diseases of the Esophagus, 2023. 36: p. 37-38. 

Prevost, G.A., et al., RefluxStop™, a novel device to address gastroesophageal reflux disease: Short-termresults. British Journal of Surgery, 2021. 108(SUPPL 4): p. iv2. https://www.researchgate.net/publication/351950490_RefluxStopTM_a_novel_device_to_address_gastroesophageal_reflux_disease_Short-term_results?__cf_chl_rt_tk=EFR78PFUD26Yvlio4F0pG3M8Qc5rkSxhn_ujK5TH6Uc-1787266740-1.0.1.1-367OuLUD8UCO8k57ixIBPFrMQD_405rdZYCmXQPWxq0

Hoffsten J, Das S, Kartha M. EE479 The Cost of Treating Gastroesophageal Reflux Disease: A Systematic Review. Value in Health. 2023;26(12):S143 https://doi.org/10.1016/j.jval.2023.09.745.

Goldsmith P, Das S, Hoffsten J. OGBN O03 Quality of Life of Patients with Gastroesophageal Reflux Disease: Findings From a Systematic Literature Review. British Journal of Surgery. 2023;110(Supplement_8) https://doi.org/10.1093/bjs/znad348.025.

*Non-exhaustive list of systematic and narrative reviews, position papers, expert perspectives, non-PubMed-indexed articles, and selected foreign-language publications that mention or discuss RefluxStop, including publications by both authors involved in RefluxStop clinical research and independent investigators.